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Why Use Enzymar Botanical Products?

Enzymar Botanical Products are solutions composed of three medically proven methods of wound cleansing and care.

First the base solution is a saline solution made from purified water and natural sea salt, in order to keep the natural elements found in sea salt vs. the laboratory processed salt. In studies such as the study in wound cleansing by the College of Athletic/Physical Therapy at U. of North Florida, “Normal Saline is regarded as the most appropriate and preferred cleansing solution”

Second is a low strength hypochlorite solution <0.15% , because it has been proven that FULL strength and even half strength hypochlorite solutions although very effective in the early grossly infected stage, can be harmful in the more chronic stage of healing. Many solutions in their Full and even half strength may cause DAMAGE and DESTROY cells essential to the healing process. Examples of these kinds of solutions are Full Strength Hypochlorite solutions, Hydrogen peroxide, Acids, Iodine solutions and scrubs which can kill and destroy healthy cells and stunt the Healing process.

Third it contains Lactoferrin, which is a naturally occurring protein found in mammalian exocrine secretions, such as milk, with broad immunomodulatory, anti-inflammatory and anti-infective properties. Recent in-vivo and in-vitro studies suggest that Lactoferrin promotes WOUND HEALING. Lactoferrin is a member of the transferring family of non-heme iron binding proteins found in external secretions such as milk, saliva, tears, seminal fluid, sweat and mucus. Also found in secondary glandules of neutrophils, main source of Lactoferrin in plasma. Several physiologic Functions, such as broad spectrum anti-infective, immunomodulatory, and anti-inflammatory activities have been attributed to Lactoferrin. In a study by Engelmayer/Vadhachary MD,PhD Wounds,2003;15(9) says “Lactoferrin exerts both bacteriostatic and bactericidal effects on bacteria by binding iron necessary for bacterial growth and destabilizing the outer membranes of bacteria.” “Lactoferrin has been shown to inhibit the growth of yeast, Fungi and protozoa…” “Bacterial infections inhibit wound healing; the anti-infective and immunomodulatory properties of Lactoferrin could be seen as relevant to wound healing, especially DIABETIC ulcers, a condition where infections are common.


Lactoferrin Induces Collagen Matrix Reorganization

Lactoferrin promotes collagen-gel contraction through motility of fibroblasts. Migration for 24 hours of WI-38 fibroblats on collagen-coated dishes in the presence or absence of bovine lactoferrin toward a wounded area scratched with a silicone cell scraper. Similar results were obtained with human lactoferrin.

(sources: Wounds © 2003 Health Management Publications, inc. & medscape.com)

Fibroblast motility is mediated by inducing phosphorylation of the myosin light chain (MLC). Upper panel: 12-hr cultured WI-38 fibroblasts were incubated with 1 mM of lactoferrin harvested and analyzed by Western blot to detect phosphorylated serine 19 residue of MLC (PMLC) or total MLC. LPA (lysophosphatidic acid) 10 nM served as a positive control. Lower panel: Same analysis as in the upper panel except that cells were incubated in the presence or absence of inhibitors of kinases involved in MLC phosphorylation. Y 27632: Rho kinase inhibitor. ML-7: myosin light chain kinase (MLCK) inhibitor. Adapted with permission from: Takayama Y, Mizumachi K. Effects of lactoferrin on collagen gel contractile activity and myosin light chain phosphorylation in human fibroblasts. FEBS Letters 2001;508:111-6.

(sources: Wounds © 2003 Health Management Publications, inc. & medscape.com)

Lactoferrin Studies

• Metz-Boutigue MH, Jolles J, Mazurier J, et al. Human lactotransferrin: Amino acid sequence and structural comparisons with other transferrins. Eur J Biochem 1984;145:659-76.
• Vorland LH. Lactoferrin: A multifunctional glycoprotein. APMIS 1999;107:971-81.
• Ward P, Uribe-Luna S, Conneely OM. Lactoferrin and host defense. Biochem Cell Biol 2002;80:95-102.
• Anderson BF, Baker HM, Norris GE, et al. Structure of human lactoferrin: crystallographic structure analysis and refinement at 2.8 C5 resolution. J Mol Biol 1989;209:711-34.
• Headon DR. Human lactoferrin: production at large scale, characterization and applications. In: Shimazaki K, Tsuda H, Tomita M, et al (eds). Lactoferrin: Structure, Function and Applications. Amsterdam: Elsevier Science, 2000;415-27.
• Swart PJ, Kuipers EM, Smit C, et al. Antiviral activity of lactoferrin. Adv Exp Med Biol 1998;443:205-13.
• Groves RW, Schmidt-Lucke JA. Recombinant human GM-CSF in the treatment of poorly healing wounds. Adv Skin Wound Care 2000;13(3 Pt 1):107-12.
• Edmonds M, Bates M, Doxford M, et al. Diabetes New treatments in ulcer healing and wound infection. Metab Res Rev 2000;16(Suppl 1):S51-4.
• Engelmayer J, Varadhachary A. Recombinant human lactoferrin accelerates wound healing. Wound Repair Regen 2003;11:A25.

Help healing with Enzymar.

By using the Enzymar Scrub (soap solution) at the beginning of the treatment, it will remove the debris, dirt and secretions of grossly infected wounds, followed by Enzymar Spray Solution (clear solution) to promote healing and maintain a clean low bacterial count and finally the Enzymar Lotion in the crusted final stage of the healing process to maintain a moisturized and clean skin. ENZYMAR Botanical Products combines 2 proven formulas that have worked for decades and Lactoferrin which has been proven scientifically in multiple studies, a natural protein produced by our own body.